Title: Melagatran
CAS Registry Number: 159776-70-2
CAS Name: N-[(1R)-2-[(2S)-2-[[[[4-(Aminoiminomethyl)phenyl]methyl]amino]carbonyl]-1-azetidinyl]-1-cyclohexyl-2-oxoethyl]glycine
Additional Names: N-[(R)-[[(2S)-2-[[p-amidinobenzyl]carbamoyl]-1-azetidinyl]carbonyl]cyclohexylmethyl]glycine
Manufacturers' Codes: H-319/68
Molecular Formula: C22H31N5O4
Molecular Weight: 429.51
Percent Composition: C 61.52%, H 7.27%, N 16.31%, O 14.90%
Literature References: Synthetic thrombin inhibitor. Prepn: K. T. Antonsson et al., WO 9429336; eidem, US 5939392 (1994, 1999 both to Astra AB). Pharmacology: D. Gustafsson et al., Thromb. Haemostasis 79, 110 (1998). Clinical evaluation in patients with deep vein thrombosis: H. Eriksson et al., ibid. 81, 358 (1999).
Therap-Cat: Antithrombotic.
Keywords: Antithrombotic. |