Title: Melinamide
CAS Registry Number: 14417-88-0
CAS Name: (Z,Z)-N-(1-Phenylethyl)-9,12-octadecadienamide
Additional Names: N-(a-methylbenzyl)linoleamide; MBLA
Manufacturers' Codes: AC-223
Trademarks: Artes (Sumitomo)
Molecular Formula: C26H41NO
Molecular Weight: 383.61
Percent Composition: C 81.41%, H 10.77%, N 3.65%, O 4.17%
Literature References: Linoleic acid derivative. Prepn and use in lowering blood cholesterol levels: FR 1476596; T. Seki et al., US 3621043 (1967, 1971 both to Sumitomo). Physical properties and effect on cholesterol levels in rabbits: K. Toki et al., J. Atheroscler. Res. 7, 708 (1967). Comparative activity of melinamide and its optical isomers: H. Fukushima, K. Nakatani, ibid. 9, 65 (1969); H. Fukushima et al., ibid. 10, 403 (1969). Mechanism of action studies: D. Kritchevsky, S. A. Tepper, Arzneim.-Forsch. 21, 1024 (1971); D. Kritchevsky et al., Lipids 12, 16 (1977); K. Natori et al., Jpn. J. Pharmacol. 42, 517 (1986). Metabolism: A. Hirohashi et al., Xenobiotica 6, 329 (1976).
Properties: Oil. mp <4°. bp0.03 200-215°; bp0.07 200-204°. nD23 1.5050; nD30 1.4863. Saponification value 0.9. Iodine value 127.0.
Melting point: mp <4°
Boiling point: bp0.03 200-215°; bp0.07 200-204°
Index of refraction: nD23 1.5050; nD30 1.4863
Therap-Cat: Antilipemic.
Keywords: Antilipemic. |