Title: Mepindolol
CAS Registry Number: 23694-81-7
CAS Name: 1-[(1-Methylethyl)amino]-3-[(2-methyl-1H-indol-4-yl)oxy]-2-propanol
Additional Names: 1-(isopropylamino)-3-[(2-methylindol-4-yl)oxy]-2-propanol
Molecular Formula: C15H22N2O2
Molecular Weight: 262.35
Percent Composition: C 68.67%, H 8.45%, N 10.68%, O 12.20%
Literature References: b-Adrenergic blocker; the 2-methyl analog of pindolol, q.v. Prepn: F. Troxler, CH 469002 and CH 472404 (both 1969 to Sandoz); F. Seeman et al., Helv. Chim. Acta 54, 2411 (1971). Pharmacokinetics: R. Gugler et al., Arzneim.-Forsch. 25, 1067 (1975). Pharmacodynamics: J. Bonelli et al., Eur. J. Clin. Pharmacol. 15, 1 (1979). Clinical studies: H. M. Beumer et al., Int. J. Clin. Pharmacol. Biopharm. 16, 249 (1978); M. Sukerman et al., Curr. Ther. Res. 25, 384 (1979).
Properties: Crystals from ethyl acetate, mp 100-102° (Seeman). Also reported as 95-97° (Troxler).
Melting point: mp 100-102° (Seeman). Also reported as 95-97° (Troxler)
Derivative Type: Sulfate salt
CAS Registry Number: 56396-94-2
Manufacturers' Codes: SH-E-222
Trademarks: Betagon (Schering AG); Corindolan (Schering AG); Mepicor (Corvi)
Molecular Formula: (C15H22N2O2)2.H2SO4
Molecular Weight: 622.77
Percent Composition: C 57.86%, H 7.45%, N 9.00%, O 20.55%, S 5.15%
Therap-Cat: Antihypertensive; antianginal.
Keywords: ?Adrenergic Blocker; Antianginal; Antihypertensive; Aryloxypropanolamine Derivatives. |