Title: Methylcobalamin
CAS Registry Number: 13422-55-4
CAS Name: Cobinamide Co-methyl deriv. dihydrogen phosphate (ester) inner salt 3¢-ester with 5,6-dimethyl-1-a-D-ribofuranosyl-1H-benzimidazole
Additional Names: methyl-5,6-dimethylbenzimidazolylcobalamin; mecobalamin; methyl vitamin B12; MeCbl
Trademarks: Algobaz (Labaz); Hitocobamin-M (Hishiyama); Methycobal (Eisai); Methylcobaz (Labaz)
Molecular Formula: C63H91CoN13O14P
Molecular Weight: 1344.38
Percent Composition: C 56.28%, H 6.82%, Co 4.38%, N 13.54%, O 16.66%, P 2.30%
Literature References: One of the biologically active forms of vitamin B12, q.v.; differing only by the substitution of a methyl for the cyano group. Coenzyme required in the biosynthesis of methionine. Identification as requirement for methionine biosynthesis by E. coli: R. L. Kisliuk, D. D. Woods, Biochem. J. 75, 467 (1960); J. R. Guest et al., Nature 195, 340 (1962). Prepn: O. Müller, G. Müller, Biochem. Z. 336, 299 (1962); D. Dolphin, Methods Enzymol. 18, Pt. C, 34 (1971); D. Autissier et al., Bull. Soc. Chim. Fr. 1980, part 2, 192. Interrelationship with folate metabolism: B. Shane, E. L. R. Stokstad, Annu. Rev. Nutr. 5, 115-141 (1985). Discussion of mechanism of action: W. S. Beck, Am. J. Hematol. 34, 83-89 (1990). Review: "Vitamin B12" in Vitamins, W. Friedrich, Ed. (de Gruyter, Berlin, 1988) pp 837-928.
Properties: Bright red crystals from water/acetone. uv max (pH 7): 522, 342, 266 nm (e 9357, 14416, 19897); (0.1N HCl): 462, 304, 264 nm (e 9599, 22855, 24737).
Absorption maximum: uv max (pH 7): 522, 342, 266 nm (e 9357, 14416, 19897); (0.1N HCl): 462, 304, 264 nm (e 9599, 22855, 24737)
Therap-Cat: Vitamin (hematopoietic).
Keywords: Vitamin/Vitamin Source; Vitamin B12. |