Title: Metolazone
CAS Registry Number: 17560-51-9
CAS Name: 7-Chloro-1,2,3,4-tetrahydro-2-methyl-3-(2-methylphenyl)-4-oxo-6-quinazolinesulfonamide
Additional Names: 7-chloro-1,2,3,4-tetrahydro-2-methyl-4-oxo-3-o-tolyl-6-quinazolinesulfonamide; 2-methyl-3-o-tolyl-6-sulfamyl-7-chloro-1,2,3,4-tetrahydro-4-quinazolinone
Manufacturers' Codes: SR-720-22
Trademarks: Metenix (Sanofi-Aventis); Mykrox (Celltech); Xuret (Galen); Zaroxolyn (Teofarma)
Molecular Formula: C16H16ClN3O3S
Molecular Weight: 365.83
Percent Composition: C 52.53%, H 4.41%, Cl 9.69%, N 11.49%, O 13.12%, S 8.77%
Literature References: Prepn: B. V. Shetty, US 3360518 (1967 to Wallace & Tiernan); B. V. Shetty et al., J. Med. Chem. 13, 886 (1970). Pharmacology: E. Belair et al., Arch. Int. Pharmacodyn. Ther. 177, 71 (1969); E. J. Belair, Res. Commun. Chem. Pathol. Pharmacol. 2, 98 (1971). HPLC determn in urine: D. Farthing et al., J. Chromatogr. 534, 228 (1990). Clinical evaluations as diuretic in chronic renal disease: R. Schoonees et al., N. Y. State J. Med. 71, 566 (1971); in hypertension: C. L. Curry et al., Clin. Ther. 9, 47 (1986); in congestive heart failure: A. Kiyingi et al., Lancet 335, 29 (1990).
Properties: Crystals from ethanol or butanol, mp 252-254°. LD50 in mice (mg/kg): >5000 orally; >1500 i.p. (Shetty, 1967).
Melting point: mp 252-254°
Toxicity data: LD50 in mice (mg/kg): >5000 orally; >1500 i.p. (Shetty, 1967)
Therap-Cat: Diuretic; antihypertensive.
Keywords: Antihypertensive; Thiazides and Analogs; Diuretic; Thiazides and Analogs. |