Title: Nalbuphine
CAS Registry Number: 20594-83-6
CAS Name: (5a,6a)-17-(Cyclobutylmethyl)-4,5-epoxymorphinan-3,6,14-triol
Additional Names: N-cyclobutylmethyl-14-hydroxydihydronormorphine
Molecular Formula: C21H27NO4
Molecular Weight: 357.44
Percent Composition: C 70.56%, H 7.61%, N 3.92%, O 17.90%
Literature References: Mixed opioid agonist-antagonist. Prepn: GB 1119270 corresp to I. J. Pachter, Z. Matossian, US 3393197 (both 1968 to Endo). Pharmacology: S. G. Holtzman, Probl. Drug Depend. 1976, 374; H. E. Shannon, S. G. Holtzman, J. Pharmacol. Exp. Ther. 201, 55 (1977); G. J. Schaefer, S. G. Holtzman, ibid. 205, 291 (1978). Plasma determn: S. H. Weinstein et al., J. Pharm. Sci. 67, 547 (1978). Clinical study: T. Tammisto, I. Tigerstedt, Acta Anaesthesiol. Scand. 21, 390 (1977). Review of pharmacology and therapeutic efficacy: J. K. Errick, R. C. Heel, Drugs 26, 191-211 (1983).
Properties: Cryst from methanol-acetone, mp 230.5°.
Melting point: mp 230.5°
Derivative Type: Hydrochloride
CAS Registry Number: 23277-43-2
Manufacturers' Codes: EN-2234A
Trademarks: Nubain (Endo)
Molecular Formula: C21H27NO4.HCl
Molecular Weight: 393.90
Percent Composition: C 64.03%, H 7.16%, N 3.56%, O 16.25%, Cl 9.00%
Therap-Cat: Analgesic (narcotic).
Keywords: Analgesic (Narcotic). |