Title: Nicofibrate
CAS Registry Number: 31980-29-7
CAS Name: 2-(4-Chlorophenoxy)-2-methylpropanoic acid 3-pyridinylmethyl ester
Additional Names: 2-(p-chlorophenoxy)-2-methylpropionic acid 3-pyridylmethyl ester; 3-hydroxymethylpyridine p-chlorophenoxyisobutyrate; clofenpyride
Molecular Formula: C16H16ClNO3
Molecular Weight: 305.76
Percent Composition: C 62.85%, H 5.27%, Cl 11.60%, N 4.58%, O 15.70%
Literature References: Prepn: NL 6610738 corresp to Bolhofer, US 3369025 (1967, 1968, both to Merck & Co.); Nakanishi et al., JP 68 14466 (1968 to Yoshitomi); Garzia, DE 1948320 (1970 to Ist. Chem. Ital.). Pharmacology: Marmo et al., Farmaco Ed. Prat. 26, 557 (1971).
Properties: mp 48-49°. bp0.4 180°.
Melting point: mp 48-49°
Boiling point: bp0.4 180°
Derivative Type: Hydrochloride
CAS Registry Number: 17413-51-3
Trademarks: Arterium V (Schwarz)
Molecular Formula: C16H16ClNO3.HCl
Molecular Weight: 342.22
Percent Composition: C 56.15%, H 5.01%, Cl 20.72%, N 4.09%, O 14.03%
Properties: Crystals from ethyl acetate, mp 115.5-118.5°.
Melting point: mp 115.5-118.5°
Therap-Cat: Antilipemic.
Keywords: Antihyperlipoproteinemic; Fibrates.
Status: This monograph has been retired and is no longer subject to revision or update. |