Title: Nomifensine
CAS Registry Number: 24526-64-5
CAS Name: 1,2,3,4-Tetrahydro-2-methyl-4-phenyl-8-isoquinolinamine
Additional Names: 8-amino-1,2,3,4-tetrahydro-2-methyl-4-phenylisoquinoline
Molecular Formula: C16H18N2
Molecular Weight: 238.33
Percent Composition: C 80.63%, H 7.61%, N 11.75%
Literature References: Novel antidepressant distinguished from existing tricyclic and tetracyclic antidepressants by its bicyclic structure. Prepn: GB 1164192 corresp to G. Ehrhart et al., US 3577424 (1969, 1971, both to Farbwerke Hoechst); I. Hoffmann et al., Arzneim.-Forsch. 21, 1045 (1971). Pharmacology: I. Hoffmann, ibid. 23, 45 (1973); P. Hunt et al., J. Pharm. Pharmacol. 26, 370 (1974); B. Costall et al., Psychopharmacologia 41, 153 (1975). Pharmacokinetics: L. Vereczkey et al., ibid. 45, 225 (1975). Study on abuse potential in humans: C. Spyraki, H. C. Fibiger, Science 212, 1167 (1981). Review: Br. J. Clin. Pharmacol. 4, Suppl. 2 (1977) pp 1S-248S; Int. Pharmacopsychiatry 17, Suppl. 1 (1982) pp 1-148.
Properties: mp 179-181°.
Melting point: mp 179-181°
Derivative Type: Maleate
CAS Registry Number: 32795-47-4
Manufacturers' Codes: HOE-984
Trademarks: Alival (Hoechst); Hostalival (Hoechst); Merital (Hoechst); Neurolene (Magis); Psicronizer (Albert-Pharma)
Molecular Formula: C16H18N2.C4H4O4
Molecular Weight: 354.40
Percent Composition: C 67.78%, H 6.26%, N 7.90%, O 18.06%
Properties: Crystals from ethanol, mp 199-201°. LD50 in mice, rats (mg/kg): 400, 430 orally; 90, 72 i.v.; in mice (mg/kg): 410 s.c. (Hoffman, 1973).
Melting point: mp 199-201°
Toxicity data: LD50 in mice, rats (mg/kg): 400, 430 orally; 90, 72 i.v.; in mice (mg/kg): 410 s.c. (Hoffman, 1973)
Therap-Cat: Antidepressant.
Keywords: Antidepressant; Bicyclics. |