Title: Olaflur
CAS Registry Number: 6818-37-7
CAS Name: 2,2¢-[[3-[(2-Hydroxyethyl)octadecylamino]propyl]imino]bisethanol dihydrofluoride
Additional Names: AmF 297; amine fluoride 297; N-(diethanolaminopropyl)-N-(ethanol)octadecylamine dihydrofluoride; N,N,N¢-tris(2-hydroxyethyl)-N¢-octadecyl-1,3-diaminopropane dihydrofluoride
Manufacturers' Codes: SKF-38095
Trademarks: RonaCare (Merck KGaA)
Molecular Formula: C27H58N2O3.2HF
Molecular Weight: 498.77
Percent Composition: C 65.02%, H 12.13%, N 5.62%, O 9.62%, F 7.62%
Literature References: Anticariogenic organic amine fluoride; often used in combination with stannous fluoride or sodium fluoride, q.q.v. Reduces surface tension of saliva, forming a protective film on tooth surfaces. Prepn: H. Schmid, H. R. Mühlemann, US 3083143 (1963 to GABA). In vitro antimicrobial activity: H. M. Kay, M. Wilson, J. Periodontol. 59, 266 (1988). Adsorption and desorption to hydroxyapatite: J. Sefton et al., Biomaterials 17, 37 (1996). Clinical evaluation of caries inhibition in children: T. M. Marthaler, Br. Dent. J. 119, 153 (1965); of effects on plaque and gingivitis in adults: L. Shapira et al., J. Int. Acad. Periodontol. 4, 117 (1999); of reduction of erosion in enamel and dentine: C. Ganss et al., Caries Res. 38, 561 (2004).
Properties: Sol in water, ethanol, methanol. Aq soln foams. Slightly acidic pH.
Use: Dental caries prophylactic. |