Title: Ornipressin
CAS Registry Number: 3397-23-7
CAS Name: 8-L-Ornithinevasopressin
Additional Names: orn(8)-vasopressin
Manufacturers' Codes: POR-8
Molecular Formula: C45H63N13O12S2
Molecular Weight: 1042.19
Percent Composition: C 51.86%, H 6.09%, N 17.47%, O 18.42%, S 6.15%
Literature References: Synthetic analog of vasopressin, q.v., in which L-ornithine replaces L-arginine. Prepn: R. L. Huguenin, R. A. Boissonnas, Helv. Chim. Acta 46, 1669 (1963); eidem, FR 1396607 corresp to US 3299036 (1965, 1967 both to Sandoz). Separation by reversed-phase HPLC: K. Krummen, R. W. Frei, J. Chromatogr. 132, 27 (1977). Pharmacologic properties: B. Berde et al., Experientia 20, 42 (1964). Pharmacodynamics: S. Keppens, H. de Wulf, Biochim. Biophys. Acta 588, 63 (1979). Comparison of hemostatic and cardiovascular effects: L. Saarnivaara, P. Leander, Anaesthesist 26, 144 (1977). Clinical study: D. J. Adendorff, D. Davies, S. Afr. Med. J. 51, 131 (1977).
Therap-Cat: Vasoconstrictor.
Keywords: Antidiuretic. |