Title: Pentrinitrol
CAS Registry Number: 1607-17-6
CAS Name: 2,2-Bis[(nitrooxy)methyl]-1,3-propanediol mononitrate (ester)
Additional Names: pentaerythritol trinitrate
Manufacturers' Codes: W-2197
Trademarks: Petrin (Parke-Davis)
Molecular Formula: C5H9N3O10
Molecular Weight: 271.14
Percent Composition: C 22.15%, H 3.35%, N 15.50%, O 59.01%
Literature References: Coronary vasodilator related to pentaerythritol tetranitrate, q.v. Prepn (no data given): DE 638422; DE 638423 (both 1936 to Westfälisch-Anhaltisch Sprengstoff), C.A. 31, 12122(1937); N. J. Marans et al., J. Am. Chem. Soc. 76, 1304 (1954); A. T. Camp et al., ibid. 77, 751 (1955); J. Simecek, Collect. Czech. Chem. Commun. 27, 362 (1962). Use in coronary insufficiency: F. J. DiCarlo, US 3419571 (1968 to Warner-Lambert). Electrical moment and molecular rotation: A. R. Lawrence, A. J. Matuszko, J. Phys. Chem. 65, 1903 (1961). Chromatographic determn: I. W. F. Davidson et al., J. Chromatogr. 57, 345 (1971). Metabolism: F. J. DiCarlo et al., Clin. Pharmacol. Ther. 22, 309 (1977). Comparative duration of action: J. Vohra et al., Aust. N.Z. J. Med. 9, 554 (1979).
Properties: Viscous liq. nD20 1.4941. d420 1.554. Viscosity (cSt): 166.8 (40°); 77.8 (50°). Soly in water: 0.705 g/100 ml at 20°; in benzene: 21.40 g/100 ml at 20°. Very sol in ethanol, ether. Forms a cryst hydrate, mp 32°, when washed with water and allowed to stand overnight at 20°; returns to unhydrated form when allowed to stand at 60° for 2 hrs. When used medicinally it is usually diluted with lactose or mannitol to reduce explosive liability, see pentaerythritol tetranitrate.
Melting point: mp 32°
Index of refraction: nD20 1.4941
Density: d420 1.554
Therap-Cat: Vasodilator (coronary).
Keywords: Vasodilator (Coronary). |