Peptide YY

Literature References: 36 amino acid peptide hormone named for its N- and C-terminal tyrosine (Y) residues. Evolutionarily related to pancreatic polypeptide and neuropeptide Y, q.v.. Regulates gut motility and secretion of gastric fluids. The two main endogenous circulating forms, PYY1-36 and PYY3-36, are released from endocrine L-cells in response to caloric intake. Abnormalities in intestinal PYY are linked to many gastrointestinal disorders including obesity and diabetes. Isoln and characterization of porcine form: K. Tatemoto, V. Mutt, Nature 285, 417 (1980); K. Tatemoto, Proc. Natl. Acad. Sci. USA 79, 2514 (1982); of human form: idem et al., Biochem. Biophys. Res. Commun. 157, 713 (1988). Structural characterization of human PYY3-36 and PYY1-36: G. A. Eberlein et al., Peptides 10, 797 (1989). CD and NMR soln structure studies: D. A. Keire et al., Biochemistry 39, 9935 (2000). Review of physiologic role in digestion: F. L. C. Hill et al., Steroids 56, 77-82 (1991). Series of articles on physiological roles and clinical potential: Peptides 23, 249-407 (2002). Review of potential role in appetite regulation and obesity therapy: B. M. C. McGowan, S. R. Bloom, Curr. Opin. Pharmacol. 4, 583-588 (2004); D. Renshaw, R. L. Batterham, Curr. Drug Targets 6, 171-179 (2005).

Literature References: Produced by cleavage of the two N-terminal amino acids by dipeptidyl peptidase IV. Inhibition of food intake in rats: R. L. Batterham et al., Nature 418, 650 (2002); in mice: B. G. Challis et al., Biochem. Biophys. Res. Commun. 311, 915 (2003).