Title: Perisoxal
CAS Registry Number: 2055-44-9
CAS Name: a-(5-Phenyl-3-isoxazolyl)-1-piperidineethanol
Additional Names: 3-(2-piperidino-1-hydroxyethyl)-5-phenylisoxazole
Molecular Formula: C16H20N2O2
Molecular Weight: 272.34
Percent Composition: C 70.56%, H 7.40%, N 10.29%, O 11.75%
Literature References: Prepn: NL 6408694; H. Kano et al., US 3321475 (1965, 1967 both to Shionogi); eidem, J. Med. Chem. 10, 411 (1967). Series of articles on pharmacological properties: Oyo Yakuri 6, 1285-1338 (1972), C.A. 79, 49177h-49179k (1973). Studies on physical dependence in rats: K. Yamamoto et al., ibid. 16, 871 (1978), C.A. 90, 180250w (1979). Absorption, excretion, distribution, metabolism: J. Watanabe et al., Chem. Pharm. Bull. 27, 1075 (1979). Toxicity study: H. Kano et al., J. Med. Chem. 10, 411 (1967).
Properties: Colorless plates from 50% aq ethanol, mp 107-108°.
Melting point: mp 107-108°
Derivative Type: Citrate
CAS Registry Number: 2139-25-5
Manufacturers' Codes: S-31252
Trademarks: Isoxal (Shionogi)
Molecular Formula: (C16H20N2O2)2.C6H8O7
Molecular Weight: 736.81
Percent Composition: C 61.94%, H 6.57%, N 7.60%, O 23.89%
Properties: Colorless prisms from ethanol/acetone, mp 143-145°. LD50 s.c. in mice: 416 mg/kg (Kano).
Melting point: mp 143-145°
Toxicity data: LD50 s.c. in mice: 416 mg/kg (Kano)
Therap-Cat: Anti-inflammatory; analgesic.
Keywords: Analgesic (Non-Narcotic); Anti-inflammatory (Nonsteroidal). |