Title: Phenprobamate
CAS Registry Number: 673-31-4
CAS Name: Benzenepropanol carbamate
Additional Names: carbamic acid 3-phenylpropyl ester; 1-carbamoyloxy-3-phenylpropane; g-phenylpropyl carbamate; proformiphen
Manufacturers' Codes: MH-532
Trademarks: Extacol (Nikken); Spantol (Nippon Chemiphar); Gamaquil (Siegfried)
Molecular Formula: C10H13NO2
Molecular Weight: 179.22
Percent Composition: C 67.02%, H 7.31%, N 7.82%, O 17.85%
Line Formula: H2NCOOCH2CH2CH2C6H5
Literature References: Prepn: GB 837718 (1960 to Siegfried AG). Pharmacology: G. Stille, Arzneim.-Forsch. 12, 340 (1962). HPLC determn in plasma: J. X. S. Sun et al., Biopharm. Drug Dispos. 8, 341 (1987). Clinical pharmacokinetics: F. C. Tulunay et al., Arzneim.-Forsch. 48, 1068 (1998).
Properties: Shiny leaflets from aq ethanol, mp 101-104°. Slightly bitter, somewhat burning taste. Numbs the tongue slightly afterwards. Soluble in abs ethanol, chloroform, propylene glycol, ethylenediamine, dimethylformamide; sparingly sol in ether, 50% ethanol. Practically insol in water. LD50 orally in mice: 840 mg/kg (Stille).
Melting point: mp 101-104°
Toxicity data: LD50 orally in mice: 840 mg/kg (Stille)
Therap-Cat: Muscle relaxant (skeletal).
Keywords: Muscle Relaxant (Skeletal). |