Title: Phorate
CAS Registry Number: 298-02-2
CAS Name: Phosphorodithioic acid O,O-diethyl S-[(ethylthio)methyl] ester
Additional Names: O,O-diethyl S-(ethylthio)methyl phosphorodithioate; O,O-diethyl S-ethylmercaptomethyl dithiophosphate
Manufacturers' Codes: AC-3911; EI-3911; ENT-24042
Trademarks: Rampart (Platte Chemical); Thimet (BASF)
Molecular Formula: C7H17O2PS3
Molecular Weight: 260.38
Percent Composition: C 32.29%, H 6.58%, O 12.29%, P 11.90%, S 36.94%
Literature References: Cholinesterase inhibitor. Prepn: Schrader, Lorenz, US 2759010; GB 797307 (1956, 1958 both to Bayer). Metabolism: J. B. Bowman, J. E. Casida, J. Agric. Food Chem. 5, 192 (1957). Persistence in soil: D. L. Suett, Pestic. Sci. 6, 385 (1975). Toxicity study: T. B. Gaines, Toxicol. Appl. Pharmacol. 14, 515 (1969).
Properties: Clear liquid, bp0.1 75-78°, bp0.8 118-120°, bp2.0 125-127°. d425 1.156. nD25 1.5329. Vapor pressure at 20°: 8.4 ´ 10-4 mm Hg. Soly: 50 ppm in water. Misc with xylene, carbon tetrachloride, dioxane, methyl cellosolve, dibutyl phthalate, vegetable oils. Stable at room temp. Hydrolyzed in the presence of water and alkali. LD50 in female, male rats (mg/kg): 1.1, 2.3 orally; 2.5, 6.2 dermally (Gaines).
Boiling point: bp0.1 75-78°; bp0.8 118-120°; bp2.0 125-127°
Index of refraction: nD25 1.5329
Density: d425 1.156
Toxicity data: LD50 in female, male rats (mg/kg): 1.1, 2.3 orally; 2.5, 6.2 dermally (Gaines)
CAUTION: Potential symptoms of overexposure are irritation of eyes, skin, respiratory system; miosis; rhinorrhea; headache, chest tightness, wheezing, laryngeal spasms, salivation, cyanosis; anorexia, nausea, vomiting, abdominal cramps, diarrhea; sweating; muscle fasciculations, weakness, paralysis; giddiness, confusion, ataxia; convulsions, coma; low blood pressure; cardiac irregularities. See NIOSH Pocket Guide to Chemical Hazards (DHHS/NIOSH 97-140, 1997) p 252.
Use: Insecticide. |