Title: Pilsicainide
CAS Registry Number: 88069-67-4
CAS Name: N-(2,6-Dimethylphenyl)tetrahydro-1H-pyrrolizine-7a(5H)-acetamide
Additional Names: tetrahydro-1H-pyrrolizine-7a(5H)-aceto-2¢,6¢-xylidide; N-(2,6-dimethylphenyl)-8-pyrrolizidineacetamide
Molecular Formula: C17H24N2O
Molecular Weight: 272.39
Percent Composition: C 74.96%, H 8.88%, N 10.28%, O 5.87%
Literature References: Structural analog of lidocaine, q.v. Prepn: S. Miyano et al., EP 89061; eidem, US 4564624 (1983, 1986 both to Suntory); eidem, J. Med. Chem. 28, 714 (1985). Pharmacology: K. Aisaka et al., Arzneim.-Forsch. 35, 1239 (1985); T. Hidaka et al., ibid. 1381. Clinical evaluation in supraventricular tachycardia: T. Terazawa et al., Am. Heart J. 121, 1437 (1991).
Derivative Type: Hydrochloride hemihydrate
CAS Registry Number: 88069-49-2
Manufacturers' Codes: SUN-1165
Trademarks: Sunrythm (Suntory)
Molecular Formula: C17H24N2O.HCl.½H2O
Molecular Weight: 317.85
Percent Composition: C 64.24%, H 8.24%, N 8.81%, O 7.55%, Cl 11.15%
Properties: Crystals from ethanol-ether, mp 212-214°. LD50 in mice (mg/kg): 410 s.c. (Miyano, 1985).
Melting point: mp 212-214°
Toxicity data: LD50 in mice (mg/kg): 410 s.c. (Miyano, 1985)
Therap-Cat: Antiarrhythmic.
Keywords: Antiarrhythmic. |