Title: Pirazolac
CAS Registry Number: 71002-09-0
CAS Name: 4-(4-Chlorophenyl)-1-(4-fluorophenyl)-1H-pyrazole-3-acetic acid
Manufacturers' Codes: ZK-76604
Molecular Formula: C17H12ClFN2O2
Molecular Weight: 330.74
Percent Composition: C 61.73%, H 3.66%, Cl 10.72%, F 5.74%, N 8.47%, O 9.67%
Literature References: Prepn: BE 844972; H. Ahrens et al., US 4042706 (both 1977 to Schering AG); H. Biere et al., Eur. J. Med. Chem. - Chim. Ther. 17, 27 (1982). Pharmacokinetics: U. Täuber et al., Eur. J. Drug Metab. Pharmacokinet. 10, 41 (1985). Effect on arachidonic acid metabolism in human synovia: M. Kurowski et al., Curr. Med. Res. Opin. 10, 494 (1987). Preliminary clinical trial in rheumatoid arthritis: D. Symmons et al., ibid. 9, 542 (1985).
Properties: Crystals from ethanol + water, mp 148-149°. Also reported as second crystalline modification from toluene, mp 135-136°.
Melting point: mp 148-149°; mp 135-136°
Therap-Cat: Anti-inflammatory.
Keywords: Anti-inflammatory (Nonsteroidal); Arylacetic Acid Derivatives.
Status: This monograph has been retired and is no longer subject to revision or update. |