Title: Polidocanol
CAS Registry Number: 9002-92-0
CAS Name: a-Dodecyl-w-hydroxypoly(oxy-1,2-ethanediyl)
Additional Names: polyethylene glycol (9) monododecyl ether; dodecyl alcohol polyoxyethylene ether; hydroxypolyethoxydodecane; laureth 9; polyoxyethylene lauryl ether
Trademarks: Aethoxysklerol (Kreussler); Aetoxisclerol (Dexo); Atlas G-4829 (ICI); Hetoxol L-9 (Heterene Chem.)
Line Formula: C12H25(OCH2CH2)nOH
Literature References: Contains an average of nine ethylene oxide units and has an average mol wt ~600. Prepd by reaction of ethylene oxide and dodecyl alcohol: Pertsemlides, Soehring, Arzneim.-Forsch. 10, 990 (1960). Toxicology: H. S. Zipf et al., ibid. 7, 162 (1957). Review of clinical experience: P. M. Goldman, J. Dermatol. Surg. Oncol. 15, 204-209 (1989).
Properties: Sol in water, ethanol, toluene. Miscible with hot mineral, natural and synthetic oils; with fats and fatty alcohols. LD50 in mice (mg/kg): 1170 orally, 125 i.v. (Zipf).
Toxicity data: LD50 in mice (mg/kg): 1170 orally, 125 i.v. (Zipf)
Use: Solvent; nonionic emulsifier; pharmaceutic aid (surfactant); spermaticide.
Therap-Cat: Anesthetic (topical); antipruritic; sclerosing agent.
Keywords: Anesthetic (Local); Antipruritic; Sclerosing Agent. |