Title: Pranlukast
CAS Registry Number: 103177-37-3
CAS Name: N-[4-Oxo-2-(1H-tetrazol-5-yl)-4H-1-benzopyran-8-yl]-4-(4-phenylbutoxy)benzamide
Additional Names: 8-[4-(4-phenylbutoxy)benzamido]-2-(tetrazol-5-yl)-4H-1-benzopyran-4-one; 8-[p-(4-phenylbutoxy)benzoyl]amino-2-(5-tetrazolyl)-4-oxo-4H-1-benzopyran
Manufacturers' Codes: ONO-1078; ONO-RS-411
Trademarks: Onon (Ono)
Molecular Formula: C27H23N5O4
Molecular Weight: 481.50
Percent Composition: C 67.35%, H 4.81%, N 14.54%, O 13.29%
Literature References: Leukotriene antagonist. Prepn: M. Toda et al., EP 173516; eidem, US 4780469 (1986, 1988 both to Ono); H. Nakai et al., J. Med. Chem. 31, 84 (1988). Pharmacology: T. Obata et al., Adv. Prostaglandin Thromboxane Leukotriene Res. 15, 229 (1985); idem et al., ibid. 17, 540 (1987). Clinical evaluations in asthma: Y. Taniguchi et al., J. Allergy Clin. Immunol. 92, 507 (1993); H. Yamamoto et al. Am. J. Respir. Crit. Care Med. 150, 254 (1994).
Properties: Occurs as the hemihydrate. Crystals, mp 244-245°. LD50 in male mice (mg/kg): >1000 i.v. (Toda).
Melting point: mp 244-245°
Toxicity data: LD50 in male mice (mg/kg): >1000 i.v. (Toda)
Therap-Cat: Antiasthmatic.
Keywords: Antiasthmatic (Nonbronchodilator); Leukotriene Antagonist. |