Title: Pyruvate Decarboxylase
CAS Registry Number: 9001-04-1
CAS Name: Pyruvic decarboxylase
Additional Names: pyruvic carboxylase; a-carboxylase; 2-oxo-acid carboxylyase
Literature References: An enzyme found in yeast, in plants, in wheat germ and bacteria: Neuberg, Rosenthal, Biochem. Z. 51, 142 (1913); Holzer et al., ibid. 327, 331 (1956); Singer, Pensky, J. Biol. Chem. 196, 375 (1952); King, Chelelin, ibid. 208, 821 (1954); Howells, Lindstrom, J. Bacteriol. 75, 305 (1958). Cofactors: Diphosphothiamine, divalent metal ions. Catalyzes decarboxylation of a-ketoacids to aldehydes + CO2: Juni, J. Biol. Chem. 236, 2302 (1961). Structure and mechanism of action of the yeast enzyme: Schellenberger, Angew. Chem. Int. Ed. 6, 1024 (1967). Review: Utter, The Enzymes vol. 5, P. D. Boyer et al., Eds. (Academic Press, New York, 2nd ed., 1961) pp 320-323. |