Title: Rhizopterin
CAS Registry Number: 119-20-0
CAS Name: 4-[[(2-Amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl]formylamino]benzoic acid
Additional Names: p-[N-[(2-amino-4-hydroxy-6-pteridinyl)methyl]formamido]benzoic acid; p-[N-(2-amino-4-hydroxypyrimido[4,5-b]pyrazin-6-ylmethyl)formamido]benzoic acid; S.L.R. factor; formylpteroic acid
Molecular Formula: C15H12N6O4
Molecular Weight: 340.29
Percent Composition: C 52.94%, H 3.55%, N 24.70%, O 18.81%
Literature References: A folic acid factor that possesses high growth-promoting activity for Streptococcus lactis R (S. faecalis R), but almost none for Lactobacillus casei, chick and rat: Keresztesy et al., Science 97, 465 (1943). Isoln from charcoal adsorbate obtained from the purification of Rhizopus nigricans fumaric acid fermentation liquors: Rickes et al., J. Am. Chem. Soc. 69, 2749 (1947); Keresztesy, Rickes, US 2478404 (1949 to Merck & Co.). Structure: Wolf et al., J. Am. Chem. Soc. 69, 2753 (1947).
Properties: Light yellow platelets from aq ammonium acetate soln. Does not melt below 300°. Absorption spectrum: Rickes et al., J. Am. Chem. Soc. 69, 2749, 2751 (1947). Practically insol in water and the usual organic solvents. Sol in ammonia water, in aq solns of alkali hydroxides, and in pyridine.
Status: This monograph has been retired and is no longer subject to revision or update. |