Title: Salmine Sulfate
CAS Registry Number: 53597-25-4
Literature References: A protamine found in the sperm of salmon. Contains arginine, proline, serine, glycine, valine, leucine, alanine, threonine, isoleucine, lysine, histidine, aspartic and glutamic acids. Mol wt 6000 to 7000. N about 25%. Prepn and properties: Fisher, Scott, J. Pharmacol. Exp. Ther. 58, 78 (1936); Felix, Am. Sci. 43, 431 (1955); Callanan et al., J. Biol. Chem. 229, 279 (1957); Carroll et al., ibid. 234, 2314 (1959). Separation of components and amino acid sequence of major component: Ando, Watanabe, Int. J. Protein Res. 1, 221 (1969). Toxicity study: Starbuck et al., Arch. Int. Pharmacodyn. Ther. 165, 374 (1967).
Properties: Salmine base is a powder sol in disodium phosphate buffer; the sulfate separates from water in the cold as a clear, immiscible liquid. LD50 i.v. in rats: 75 mg/kg (Starbuck).
Toxicity data: LD50 i.v. in rats: 75 mg/kg (Starbuck) |