Title: Samarium 153Sm Lexidronam
CAS Registry Number: 154427-83-5
CAS Name: (OC-6-21)-[[[1,2-Ethanediylbis[(nitrilo-kN)bis(methylene)]]tetrakis[phosphonato-kO]](8-)]-samarate(5-)-153Sm
Additional Names: samarium 153 ethylenediaminetetramethylenephosphonic acid; 153Sm-EDTMP
Molecular Formula: C6H12N2O12P4153Sm
Literature References: Tetraphosphonate chelating agent bound to a b-emitting radionuclide; targets areas of increased bone turnover. Prepn: J. Simon et al., EP 164843; eidem, US 4898724 (1985, 1990 both to Dow); W. F. Goeckeler et al., Nucl. Med. Biol. 13, 479 (1986). Biodistribution studies: idem et al., J. Nucl. Med. 28, 495 (1987). Pharmacokinetics and clinical evaluation of pain palliation in metastatic bone cancer: M. Farhanghi et al., ibid. 33, 1451 (1992). HPLC determn in urine: W. F. Goeckeler et al., Nucl. Med. Biol. 20, 657 (1993). Chromatographic determn of radiochemical purity: H. T. Gasiglia, H. Okada, J. Radioanal. Nucl. Chem. Lett. 199, 295 (1995). Review of therapeutic potential: R. A. Holmes, Semin. Nucl. Med. 22, 41-45 (1992). Clinical trial in palliation of bone pain in hormone-refractory prostate cancer: O. Sartor et al., Urology 63, 940 (2004).
Derivative Type: Pentasodium salt
CAS Registry Number: 160369-78-8
Manufacturers' Codes: CYT-424
Trademarks: Quadramet (Cytogen)
Molecular Formula: C6H12N2Na5O12P4153Sm
Therap-Cat: Antineoplastic.
Keywords: Antineoplastic (Radiation Source). |