Title: Sodium Bromide
CAS Registry Number: 7647-15-6
Trademarks: Sedoneural
Molecular Formula: BrNa
Molecular Weight: 102.89
Percent Composition: Br 77.66%, Na 22.34%
Line Formula: NaBr
Literature References: Prepd commercially by adding some excess bromine to a sodium hydroxide soln forming a mixture of bromide and bromate. The reaction products are evaporated to dryness and treated with carbon to reduce the bromate to bromide. Prepn: J. H. van der Meulen, US 1775598 (1930). Toxicity study: Smith, Hambourger, J. Pharmacol. Exp. Ther. 55, 200 (1935). Brief review of physical and chemical properties and pharmacology: T. O. Soine, C. O. Wilson, Roger's Inorganic Pharmaceutical Chemistry (Lea & Febiger, Philadelphia, 8th ed., 1967) pp 213-216.
Properties: White crystals, granules or powder; saline, feebly bitter taste. Absorbs moisture from air but is not deliquescent. d 3.21. mp 755°; volatilizes at somewhat higher temp. One gram dissolves in 1.1 ml water, about 16 ml alcohol, 6 ml methanol. The aq soln is practically neutral. pH 6.5-8.0. Keep well closed. From water of room temp, sodium bromide crystallizes with 2H2O in the form of colorless crystals. Incompat. Acids, alkaloidal and heavy metal salts. LD50 orally in rats: 3.5 g/kg (Smith, Hambourger).
Melting point: mp 755°
Density: d 3.21
Toxicity data: LD50 orally in rats: 3.5 g/kg (Smith, Hambourger)
Use: In photography.
Therap-Cat: Sedative; hypnotic; anticonvulsant.
Therap-Cat-Vet: Sedative. Has been used to control convulsions, chorea, hysteria.
Keywords: Anticonvulsant; Sedative/Hypnotic; Bromides. |