Title: Strophanthin
CAS Registry Number: 11005-63-3
Additional Names: K-Strophanthin; K-strophanthoside
Trademarks: Kombetin (Boehringer, Mann.)
Literature References: A glycoside or a mixture of glycosides obtained from Strophanthus kombé Oliv., Apocynaceae. Properly speaking K-strophanthoside contains a-glucose 19%, b-glucose 19%, cymarose 15%, strophanthidin 47%. K-Strophanthin-b (Strophosid) contains b-glucose, cymarose, and strophanthidin: Geissberger, Schweiz. Med. Wochenschr. 91, 241 (1961). Pharmacology and acute toxicity: H. Mehnert, Arch. Pharmacol. 184, 181 (1937).
Properties: White or yellowish powder contg as much as 10% water, which it does not lose entirely without decompn. Very poisonous! Stable in air, but affected by light. Soluble in water and in dil alcohol; less sol in abs alcohol. Nearly insol in chloroform, ether, benzene. Aq solns are neutral to litmus. When bioassayed, strophanthin shall possess a potency per mg equivalent to 0.5 mg of U.S.P. Ouabain Reference Standard. A deviation of 20% is permitted. MLD in cats, rats (mg/kg): 0.11, 9.4 i.v. (Mehnert).
Toxicity data: MLD in cats, rats (mg/kg): 0.11, 9.4 i.v. (Mehnert)
Derivative Type: G-strophanthin see Ouabain
Therap-Cat: Cardiotonic.
Therap-Cat-Vet: Has been used as a cardiotonic.
Keywords: Cardiotonic. |