Title: Sulfadicramide
CAS Registry Number: 115-68-4
CAS Name: N-[(4-Aminophenyl)sulfonyl]-3-methyl-2-butenamide
Additional Names: 3-methyl-N-sulfanilylcrotonamide; N1-senecioylsulfanilamide; N-sulfanilylseneciamide; N1-dimethylacroylsulfanilamide; N-sulfanilyl-b,b-dimethylacrylamide
Trademarks: Irgamide (Dispersa)
Molecular Formula: C11H14N2O3S
Molecular Weight: 254.31
Percent Composition: C 51.95%, H 5.55%, N 11.02%, O 18.87%, S 12.61%
Literature References: Prepd from b,b-dimethylacrylamide by treatment with sodamide and p-nitrobenzenesulfonyl chloride; the resulting 4-nitro-N-(b,b-dimethylacrylyl)benzenesulfonamide is reduced with Fe and dil AcOH: Martin, Häfliger, US 2417005 (1947), cf. US 2383874 (1945).
Properties: Crystals from alc. mp 184-185°. Slightly sol in water, ether. Freely sol in alcohol, acetone. For the prepn of solns the water-soluble sodium salt is marketed. A 20% aq soln of the sodium salt has a pH of 8.3.
Melting point: mp 184-185°
Therap-Cat: Antibacterial.
Keywords: Antibacterial (Synthetic); Sulfonamides. |