Title: Telithromycin
CAS Registry Number: 191114-48-4
CAS Name: 3-De[(2,6-dideoxy-3-C-methyl-3-O-methyl-a-L-ribohexopyranosyl)oxy]-11,12-dideoxy-6-O-methyl-3-oxo-12,11-[oxycarbonyl[[4-[4-(3-pyridinyl)-1H-imidazol-1-yl]butyl]imino]]erythromycin
Manufacturers' Codes: HMR-3647; RU-66647
Trademarks: Ketek (Aventis)
Molecular Formula: C43H65N5O10
Molecular Weight: 812.00
Percent Composition: C 63.60%, H 8.07%, N 8.62%, O 19.70%
Literature References: Semisynthetic macrolide antibiotic of the ketolide class, a group of erythromycin derivatives in which the L-cladinose residue has been replaced by a 3-keto group. Prepn: C. Agouridas et al., EP 680967; eidem, US 5635485 (1995, 1997 both to Roussel Uclaf); A. Denis et al., Bioorg. Med. Chem. Lett. 9, 3075 (1999). In vitro activity vs anaerobic bacteria: L. M. Ednie et al., Antimicrob. Agents Chemother. 41, 2019 (1997); vs gram-positive bacteria: K. Malathum et al., ibid. 43, 930 (1999). Time-kill kinetics: F. J. Boswell et al., J. Antimicrob. Chemother. 41, 149 (1998). HPLC analysis: B. Lingerfelt, W. S. Champney, J. Pharm. Biomed. Anal. 20, 459 (1999). Review of pharmacology and clinical trials: G. Ackermann, A. C. Rodloff, J. Antimicrob. Chemother. 51, 497-511 (2003).
Properties: Crystals from ether, mp 187-188°.
Melting point: mp 187-188°
Therap-Cat: Antibacterial.
Keywords: Antibacterial (Antibiotics); Macrolides. |