Title: Temafloxacin
CAS Registry Number: 108319-06-8
CAS Name: 1-(2,4-Difluorophenyl)-6-fluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid
Manufacturers' Codes: T-1258; A-63004
Trademarks: Teflox (Abbott); Temac (Abbott); Omniflox (Abbott)
Molecular Formula: C21H18F3N3O3
Molecular Weight: 417.38
Percent Composition: C 60.43%, H 4.35%, F 13.66%, N 10.07%, O 11.50%
Literature References: Trifluorinated quinolone antibacterial. Prepn: D. T. W. Chu, EP 131839; idem, US 4730000 (1985, 1988 to Abbott). Antibacterial activities: D. J. Hardy et al., Antimicrob. Agents Chemother. 31, 1768 (1987); K. V. I. Rolston et al., Eur. J. Clin. Microbiol. Infect. Dis. 7, 684 (1988); in comparison with other fluoroquinolones: A. L. Barry, R. N. Jones, J. Antimicrob. Chemother. 23, 527 (1989).
Derivative Type: Hydrochloride
CAS Registry Number: 105784-61-0
Manufacturers' Codes: A-62254
Molecular Formula: C21H18F3N3O3.HCl
Molecular Weight: 453.84
Percent Composition: C 55.58%, H 4.22%, F 12.56%, N 9.26%, O 10.58%, Cl 7.81%
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