Title: Velnacrine
CAS Registry Number: 104675-29-8
CAS Name: 9-Amino-1,2,3,4-tetrahydro-1-acridinol
Molecular Formula: C13H14N2O
Molecular Weight: 214.26
Percent Composition: C 72.87%, H 6.59%, N 13.07%, O 7.47%
Literature References: Cognition enhancing acetylcholinesterase inhibitor; major metabolite of tacrine. Prepn: G. M. Shutske, F. A. Pierrat, EP 179383; eidem, US 4631286 (both 1986 to Hoechst-Roussel); G. M. Shutske et al., J. Med. Chem. 31, 1278 (1988); eidem, ibid. 32, 1805 (1989). Clinical pharmacokinetics: S. K. Puri et al., J. Clin. Pharmacol. 30, 948 (1990). Pharmacology: M. F. M. Braga et al., Br. J. Pharmacol. 102, 909 (1991). Structure-activity study: D. A. Butterfield, A. Rangachari, Biochem. Biophys. Res. Commun. 185, 596 (1992). HPLC determn in biological fluids: R. S. Hsu et al., J. Chromatogr. 494, 347 (1989). Clinical evaluation in Alzheimer's disease: M. F. Murphy et al., Ann. N.Y. Acad. Sci. 640, 253 (1991).
Properties: Powder, mp 245°.
Melting point: mp 245°
Derivative Type: Maleate
CAS Registry Number: 118909-22-1
Manufacturers' Codes: HP-029
Trademarks: Mentane (Hoechst-Roussel)
Molecular Formula: C13H14N2O.C4H4O4
Molecular Weight: 330.34
Percent Composition: C 61.81%, H 5.49%, N 8.48%, O 24.22%
Properties: Crystals from methanol and ethyl acetate, mp 171-173°. LD50 in mice (mg/kg): 136 orally; 162 i.p. (Shutske 1988, 1989).
Melting point: mp 171-173°
Toxicity data: LD50 in mice (mg/kg): 136 orally; 162 i.p. (Shutske 1988, 1989)
Therap-Cat: Nootropic.
Keywords: Nootropic.
Status: This monograph has been retired and is no longer subject to revision or update. |