Title: Xaliproden
CAS Registry Number: 135354-02-8
CAS Name: 1,2,3,6-Tetrahydro-1-[2-(2-naphthalenyl)ethyl]-4-[3-(trifluoromethyl)phenyl]pyridine
Molecular Formula: C24H22F3N
Molecular Weight: 381.43
Percent Composition: C 75.57%, H 5.81%, F 14.94%, N 3.67%
Literature References: Serotonin 5HT1A-receptor agonist; enhances production of neurotrophic factors and extends motor neuron survival. Prepn: D. Nisato et al., EP 101381; eidem, US 4521428 (1984, 1985 both to Sanofi); of radiolabelled compound: N. Robic, J.-P. Noël, J. Labelled Compd. Radiopharm. 42, 109 (1999). Pharmacology and receptor binding: L. Cervo et al., Eur. J. Pharmacol. 253, 139 (1994). Effect on neuron survival: Y. Iwasaki et al., J. Neurol. Sci. 160, Suppl. 1, S92 (1998). Neuroprotective effect in animal model of multiple sclerosis: B. Bourrié et al., Proc. Natl. Acad. Sci. USA 96, 12855 (1999). Review of pharmacology and clinical potential in treatment of amyotrophic lateral sclerosis: J. Fournier et al., CNS Drug Rev. 3, 148-167 (1997).
Derivative Type: Hydrochloride
CAS Registry Number: 90494-79-4
Manufacturers' Codes: SR-57746A
Molecular Formula: C24H22F3N.HCl
Molecular Weight: 417.89
Percent Composition: C 68.98%, H 5.55%, F 13.64%, N 3.35%, Cl 8.48%
Properties: mp 255-260°.
Melting point: mp 255-260°
Therap-Cat: Neuroprotective.
Keywords: Neuroprotective; Serotonin Receptor Agonist. |