Title: Ximoprofen
CAS Registry Number: 56187-89-4
CAS Name: 4-[3-(Hydroxyimino)cyclohexyl]-a-methylbenzeneacetic acid
Additional Names: p-(3-oxocyclohexyl)hydratropic acid oxime; XIFAM; 2-[4-(3-oximinocyclohexyl)phenyl]propionic acid
Manufacturers' Codes: 13832-JL
Molecular Formula: C15H19NO3
Molecular Weight: 261.32
Percent Composition: C 68.94%, H 7.33%, N 5.36%, O 18.37%
Literature References: Nonsteroidal anti-inflammatory. Prepn: J. G. Maillard, DE 2442910; idem, US 3935255 (1975, 1976 both to Lab. Jacques Logeais). Metabolism: B. C. Mayo et al., Xenobiotica 20, 233 (1990). Clinical pharmacokinetics: I. W. Taylor et al., Br. J. Clin. Pharmacol. 32, 242 (1991). GC determn in plasma: I. W. Taylor, L. F. Chasseaud, J. Chromatogr. 495, 275 (1989). HPLC determn in urine: G. R. Morris et al., ibid. 530, 377 (1990). Clinical evaluation: M. Dougados et al., J. Rheumatol. 16, 1167 (1989).
Properties: Crystals from water/methanol, mp 178°.
Melting point: mp 178°
Therap-Cat: Anti-inflammatory.
Keywords: Anti-inflammatory (Nonsteroidal); Arylpropionic Acid Derivatives. |