Title: Aldioxa
CAS Registry Number: 5579-81-7
CAS Name: [(2,5-Dioxo-4-imidazolidinyl)ureato]dihydroxyaluminum
Additional Names: (allantoinato)dihydroxyaluminum; dihydroxy[(4,5-dihydro-2-hydroxy-5-oxo-1H-imidazol-4-yl)ureato]aluminum; aluminum dihydroxy allantoinate
Manufacturers' Codes: RC-172
Trademarks: Alanetorin (Takata; Nippon Kayaku); Alusa (Towa Yakuhin); Arlanto (Nichiiko); Ascomp (Nippon Chemiphar); Chlokale (Sawai); Isalon (Grelan); Nische (Kodama); Peptilate (Dojin)
Molecular Formula: C4H7AlN4O5
Molecular Weight: 218.10
Percent Composition: C 22.03%, H 3.24%, Al 12.37%, N 25.69%, O 36.68%
Literature References: Prepn: S. B. Mecca, US 2761867 (1956 to Schuylkill Chem.). Pharmacology: R. Cahen, J. F. Clement, Ann. Pharm. Fr. 20, 693 (1962); R Cahen, A. Pessonnier, ibid. 704. Toxicology: R. Cahen, A. Pessonnier, ibid. 623. Metabolism studies: K. Fukawa et al., Oyo Yakuri 11, 421 (1976), C.A. 88, 130701g (1978). HPLC determn in plasma: K. Hirota et al., J. Chromatogr. 277, 165 (1983). Clinical studies of combination therapy for peptic ulcer: M. Sakai et al., Jpn. Arch. Intern. Med. 31, 275 (1984); idem et al., ibid. 33, 61 (1986); idem et al., ibid. 36, 357 (1989). Review of cosmetic use and safety assessment: S. N. J. Pang, J. Am. Coll. Toxicol. 12, 237-242 (1993).
Properties: White powder. mp 230°. Insol in polar and nonpolar solvents.
Melting point: mp 230°
Use: Astringent and skin conditioning agent in cosmetics.
Therap-Cat: Antiulcerative.
Keywords: Antiulcerative. |