Title: Alpidem
CAS Registry Number: 82626-01-5
CAS Name: 6-Chloro-2-(4-chlorophenyl)-N,N-dipropylimidazo[1,2-a]pyridine-3-acetamide
Manufacturers' Codes: SL-80.0342
Trademarks: Ananxyl (Synthelabo)
Molecular Formula: C21H23Cl2N3O
Molecular Weight: 404.33
Percent Composition: C 62.38%, H 5.73%, Cl 17.54%, N 10.39%, O 3.96%
Literature References: Non-benzodiazepine tranquilizer. Prepn: J. P. Kaplan, P. George, EP 50563; eidem, US 4382938 (1982, 1983 both to Synthelabo). Pharmacology and pharmacokinetics in humans: B. Saletu et al., Int. Clin. Psychopharmacol. 1, 145 (1986). HPLC determn in human plasma: V. Ascalone et al., J. Chromatogr. 414, 101 (1987). Clinical evaluation of tranquilizing vs hypnotic effects: B. Saletu et al., Curr. Ther. Res. 40, 769 (1986). Pilot study in anxiety: S. F. Langer et al., Psychopharmacol. Bull. 24, 161 (1988). Hepatotoxicity in rats: A. Berson et al., J. Pharmacol. Exp. Ther. 299, 793 (2001).
Properties: mp 140-141°.
Melting point: mp 140-141°
Therap-Cat: Anxiolytic.
Keywords: Anxiolytic.
Status: This monograph has been retired and is no longer subject to revision or update. |