Title: Amezinium Methyl Sulfate
CAS Registry Number: 30578-37-1
CAS Name: 4-Amino-6-methoxy-1-phenylpyridazinium methyl sulfate
Manufacturers' Codes: LU-1631
Trademarks: Regulton (Knoll); Risumic (Dainippon); Supratonin (Grñenthal)
Molecular Formula: C12H15N3O5S
Molecular Weight: 313.33
Percent Composition: C 46.00%, H 4.83%, N 13.41%, O 25.53%, S 10.23%
Literature References: Sympathomimetic agent with vascular and cardiac activity. Prepn: F. Richenender, R. Kropp, DE 1912941; eidem, US 3631038 (1970, 1971 both to BASF). Series of articles on synthesis, pharmacology, mechanism of action, metabolism, pharmacokinetics, bioavailability, clinical trials: Arzneim.-Forsch. 31, 1527-1671 (1981). Acute toxicity data: H. J. Teschendorf, ibid. 1580. HPLC determn in human plasma: D. Hotz, E. Brode, J. Chromatogr. 277, 217 (1983). Disposition and identification of major metabolites in rats: K. Nambu et al., Arzneim.-Forsch. 38, 909 (1988).
Properties: Crystals from water, mp 176° (dec). LD50 in mice, rats (mg/kg): 1630, 1410 orally; 40.4, 45.5 i.v. (Teschendorf).
Melting point: mp 176° (dec)
Toxicity data: LD50 in mice, rats (mg/kg): 1630, 1410 orally; 40.4, 45.5 i.v. (Teschendorf)
Therap-Cat: Antihypotensive.
Keywords: Antihypotensive. |