Title: Amoscanate
CAS Registry Number: 26328-53-0
CAS Name: 4-Isothiocyanato-N-(4-nitrophenyl)benzeneamine
Additional Names: isothiocyanic acid p-(p-nitroanilino)phenyl ester; 4-isothiocyanato-4¢-nitrodiphenylamine; nithiocyamine
Manufacturers' Codes: C-9333-Go; CGP-4540
Molecular Formula: C13H9N3O2S
Molecular Weight: 271.29
Percent Composition: C 57.55%, H 3.34%, N 15.49%, O 11.80%, S 11.82%
Literature References: Analog of nitroscanate, q.v. Prepn: K. Antos et al., DE 1932690 (1970 to Cesk. Akad. Ved), C.A. 72, 100265 (1970); S. Rajappa et al., J. Chem. Soc. Perkin Trans. 1 1979, 2001; N. Viswanathan, R. C. Desai, Indian J. Chem. 20B, 308 (1981). Anthelmintic activity: H. P. Striebel, Experientia 32, 457 (1976); K. R. Middleton et al., ibid. 35, 243 (1979); H. G. Sen, B. N. Deb, Am. J. Trop. Med. Hyg. 30, 992 (1981). HPLC determn in human plasma: W. M. Kofi-Tsekpo, C. W. Karekezi, Drugs Exp. Clin. Res. 14, 31 (1988). Clinical pharmacology: A. B. Vaidya et al., Br. J. Clin. Pharmacol. 4, 463 (1977). Mutagenicity study: B. S. Reddy et al., Antimicrob. Agents Chemother. 22, 707 (1982). Brief review: J. I. Bruce, Int. J. Parasitol. 17, 131-140 (1987).
Properties: Crystals from acetone, mp 196-198°.
Melting point: mp 196-198°
Therap-Cat: Anthelmintic (Schistosoma).
Keywords: Anthelmintic (Nematodes); Anthelmintic (Schistosoma). |