Title: Ancrod
CAS Registry Number: 9046-56-4
CAS Name: Agkistrodon serine proteinase
Additional Names: Agkistrodon rhodostoma venom proteinase
Manufacturers' Codes: A-38414
Trademarks: Arvin (Knoll); Arwin (Knoll); Viprinex (Knoll)
Literature References: Defibrinating enzyme isolated from the venom of the Malayan pit-viper, Agkistrodon rhodostoma Boie (Calloselasma rhodostoma Boie). Glycosylated serine protease composed of 234 amino acid residues; mol wt ~35,400. Cleaves fibrinogen to form soluble, non-cross-linked fibrin and enhances the local release of tissue plasminogen activator, q.v. Isoln: NL 6502120; H. A. Reid et al., US 3657416 (1965, 1972 to Nat. Res. Dev. Corp.); K. E. Chan et al., Br. J. Haematol. 11, 646 (1965). Initial purification: M. P. Esnouf, G. W. Tunnah, ibid. 13, 581 (1967). Improved purification, chemical composition: C. Nolan et al., Methods Enzymol. 45, 205 (1976). Mechanism of action studies: W. R. Bell et al., J. Lab. Clin. Med. 91, 592 (1978); C. R. M. Prentice et al., Br. J. Haematol. 83, 276 (1993). Review of clinical pharmacology and efficacy: K. A. Illig, K. Ouriel, Semin. Vasc. Surg. 9, 303-314 (1996). Review of use in anticoagulant therapy: R. L. Soutar, J. S. Ginsberg, Crit. Rev. Oncol. Hematol. 15, 23-33 (1993); in acute ischemic stroke: R. P. Atkinson, Drugs 54, Suppl. 3, 100-108 (1997).
Properties: Colorless substance when pure, having a light powdery texture when in the freeze-dried state. Soluble in physiological saline. Absorbable on weakly basic anion exchange materials.
Therap-Cat: Anticoagulant.
Keywords: Anticoagulant. |