Title: Anecortave Acetate
CAS Registry Number: 7753-60-8
CAS Name: 21-(Acetyloxy)-17-hydroxypregna-4,9(11)-diene-3,20-dione
Additional Names: D4,9(11)-pregnadien-17a,21-diol-3,20-dione-21-acetate
Manufacturers' Codes: Al-3789
Trademarks: Retaane (Alcon )
Molecular Formula: C23H30O5
Molecular Weight: 386.48
Percent Composition: C 71.48%, H 7.82%, O 20.70%
Literature References: Angiostatic steroid. Prepn: J. Fried, E. F. Sabo, J. Am. Chem. Soc. 75, 2273 (1953); R. P. Graber et al., ibid. 4722; J. Fried, E. F. Sabo, ibid. 79, 1130 (1957). Angiostatic activity in vitro: L. G. McNatt et al., J. Ocul. Pharmacol. Ther. 15, 413 (1999); in vivo: D. BenEzra et al., Invest. Ophthalmol. Visual Sci. 38, 1954 (1997). Clinical study in age-related macular degeneration: J. S. Slakter et al., Ophthalmology 110, 2372 (2003). Review of pharmacology: A. F. Clark, Expert Opin. Invest. Drugs 6, 1867-1877 (1997); and clinical experience: S. A. Vinores, IDrugs 8, 327-334 (2005).
Properties: Crystals from acetone, mp 236-237°. [a]D +117° (c = 1.0 in CHCl3). uv max (alcohol): 238 nm (e 15500). Also reported as mp 231.5-234.5°. [a]D22 +124° (c = 1.04 in CHCl3).
Melting point: mp 236-237°; mp 231.5-234.5°
Optical Rotation: [a]D +117° (c = 1.0 in CHCl3); [a]D22 +124° (c = 1.04 in CHCl3).
Absorption maximum: uv max (alcohol): 238 nm (e 15500)
Therap-Cat: In treatment of macular degeneration.
Keywords: Macular Degeneration Treatment. |