Title: Aplaviroc
CAS Registry Number: 461443-59-4
CAS Name: 4-[4-[[(3R)-1-Butyl-3-[(R)-cyclohexylhydroxymethyl]-2,5-dioxo-1,4,9-triazaspiro[5.5]undec-9-yl]methyl]phenoxy]benzoic acid
Additional Names: (3R)-1-butyl-2,5-dioxo-3-[(1R)-1-hydroxy-1-cyclohexylmethyl]-9-[4-(4-carboxyphenyloxy)phenylmethyl]-1,4,9-triazaspiro[5.5]undecane
Molecular Formula: C33H43N3O6
Molecular Weight: 577.71
Percent Composition: C 68.61%, H 7.50%, N 7.27%, O 16.62%
Literature References: CCR5 chemokine receptor antagonist; inhibits HIV entry by blocking interaction of viral coat protein gp120 with the receptor. Prepn: H. Habashita et al., WO 02074770 (2002 to Ono); eidem, US 04082584 (2004). Study of CCR5 binding and mechanism of action: C. Watson et al., Mol. Pharmacol. 67, 1268 (2005). Antiretroviral activity in immunodeficient mice: H. Nakata et al., J. Virol. 79, 2087 (2005). Clinical pharmacokinetics: K. K. Adkison et al., Antimicrob. Agents Chemother. 49, 2802 (2005).
Derivative Type: Hydrochloride
CAS Registry Number: 461023-63-2
Manufacturers' Codes: AK-602; GW-873140; ONO-4128
Molecular Formula: C33H43N3O6.HCl
Molecular Weight: 614.17
Percent Composition: C 64.53%, H 7.22%, N 6.84%, O 15.63%, Cl 5.77%
Therap-Cat: Antiviral.
Keywords: Antiviral. |