Title: Azatadine
CAS Registry Number: 3964-81-6
CAS Name: 6,11-Dihydro-11-(1-methyl-4-piperidinylidene)-5H-benzo[5,6]cyclohepta[1,2-b]pyridine
Additional Names: 4-aza-5-(N-methyl-4-piperidinylidene)-10,11-dihydro-5H-dibenzo[a,d]cycloheptene
Molecular Formula: C20H22N2
Molecular Weight: 290.40
Percent Composition: C 82.72%, H 7.64%, N 9.65%
Literature References: Prepn: F. J. Villani, BE 647043 (1964 to Scherico); idem, US 3326924 (1967 to Schering); idem et al., J. Med. Chem. 15, 750 (1972). Pharmacology: S. Tozzi et al., Agents Actions 4, 264 (1974). Toxicity studies: H. Tanaka et al., Jitchuken Zenrinsho Kenkyuho 1, 173 (1975), C.A. 84, 25951h (1976). Clinical evaluation in allergic rhinitis: J. D. Wilson et al., N. Z. Med. J. 94, 79 (1981).
Properties: Crystals from isopropyl ether, mp 124-126°.
Melting point: mp 124-126°
Derivative Type: Dimaleate
CAS Registry Number: 3978-86-7
Manufacturers' Codes: Sch-10649
Trademarks: Bonamid (Heilmittelwerke); Idulian (Schering); Optimine (Schering); Zadine (Schering)
Molecular Formula: C20H22N2.2C4H4O4
Molecular Weight: 522.55
Percent Composition: C 64.36%, H 5.79%, N 5.36%, O 24.49%
Properties: Crystals from ethyl acetate-methanol, mp 152-154°.
Melting point: mp 152-154°
Therap-Cat: Antihistaminic.
Keywords: Antihistaminic; Tricyclics; Other Tricyclics. |