Title: Besipirdine
CAS Registry Number: 119257-34-0
CAS Name: N-Propyl-N-4-pyridinyl-1H-indol-1-amine
Additional Names: 1-(propyl-4-pyridylamino)indole
Molecular Formula: C16H17N3
Molecular Weight: 251.33
Percent Composition: C 76.46%, H 6.82%, N 16.72%
Literature References: Cholinomimetic agent with noradrenergic activity. Prepn: R. C. Effland, J. T. Klein, EP 287982 (1988 to Hoechst); idem et al., US 4970218 (1990 to Hoechst-Roussel); of hydrochloride: S. Kongsamut et al., US 5356910 (1994 to Hoechst-Roussel). HPLC determn in plasma: R. S. Hsu et al., J. Chromatogr. 572, 352 (1991). Mechanism of action study: C. P. Smith et al., Drug Dev. Res. 32, 13 (1994). Pharmacokinetics: J. W. Hubbard et al., J. Clin. Pharmacol. 35, 688 (1995).
Derivative Type: Hydrochloride
CAS Registry Number: 130953-69-4
Manufacturers' Codes: HP-749
Molecular Formula: C16H17N3.HCl
Molecular Weight: 287.79
Percent Composition: C 66.77%, H 6.30%, N 14.60%, Cl 12.32%
Properties: Crystals from methanol, mp 212-214°.
Melting point: mp 212-214°
Derivative Type: Maleate
CAS Registry Number: 119257-40-8
Molecular Formula: C16H17N3.C4H4O4
Molecular Weight: 367.40
Percent Composition: C 65.38%, H 5.76%, N 11.44%, O 17.42%
Properties: Crystals from methanol/ether, mp 115-116°.
Melting point: mp 115-116°
Therap-Cat: Nootropic.
Keywords: Nootropic. |