Title: Binodenoson
CAS Registry Number: 144348-08-3
CAS Name: 2-[(Cyclohexylmethylene)hydrazino]adenosine
Manufacturers' Codes: MRE-0470; WRC-0470
Molecular Formula: C17H25N7O4
Molecular Weight: 391.42
Percent Composition: C 52.16%, H 6.44%, N 25.05%, O 16.35%
Literature References: A2A-adenosine receptor agonist, more selective than adenosine, q.v. Prepn: R. A. Olsson, R. D. Thompson, EP 567094; eidem, US 5278150 (1993, 1994 both to Whitby Research); K. Niiya et al., J. Med. Chem. 35, 4557 (1992). Dose ranging and clinical evaluation as coronary vasodilator in myocardial imaging: J. E. Udelson et al., Circulation 109, 457 (2004). Clinical pharmacokinetics: R. J. Barrett et al., J. Nucl. Cardiol. 12, 166 (2005). Review: A. Zaza, Curr. Opin. Cardiovasc. Pulm. Renal Invest. Drugs 1, 301-306 (1999).
Properties: Crystals from methanol/water, mp 154-157°.
Melting point: mp 154-157°
Therap-Cat: Diagnostic aid (cardiac stress testing).
Keywords: Diagnostic Aid; Vasodilator (Coronary); Adenosine Receptor Agonist. |