Title: Buflomedil
CAS Registry Number: 55837-25-7
CAS Name: 4-(1-Pyrrolidinyl)-1-(2,4,6-trimethoxyphenyl)-1-butanone
Additional Names: 2¢,4¢,6¢-trimethoxy-4-(1-pyrrolidinyl)butyrophenone; (2,4,6-trimethoxyphenyl)-(3-pyrrolidinopropyl) ketone
Molecular Formula: C17H25NO4
Molecular Weight: 307.38
Percent Composition: C 66.43%, H 8.20%, N 4.56%, O 20.82%
Literature References: Prepn: L. Lafon, DE 2122144; idem, US 3895030 (both 1971 to Orsymonde). Pharmacology: J. Duteil et al., Therapie 30, 207 (1975); C. Debray et al., ibid. 259. HPLC determn: J. A. Badmin et al., J. Chromatogr. 172, 319 (1979). Clinical pharmacokinetics: U. Gundert-Remy et al., Eur. J. Clin. Pharmacol. 20, 459 (1981). Comparative safety and efficacy study: G. Rosas et al., Angiology 32, 291 (1981). Review of pharmacology and therapeutic effects: S. P. Clissold et al., Drugs 33, 430-460 (1987).
Derivative Type: Hydrochloride
CAS Registry Number: 35543-24-9
Manufacturers' Codes: LL-1656
Trademarks: Bufedil (Abbott); Buflan (Fournier); Buflocit (CT); Buflonat (Nattermann); Fonzylane (Orsymonde); Irrodan (Biomed. Foscama); Lofton (Abbott); Loftyl (Abbott); Provas (Sanol Schwarz)
Molecular Formula: C17H25NO4.HCl
Molecular Weight: 343.85
Percent Composition: C 59.38%, H 7.62%, N 4.07%, O 18.61%, Cl 10.31%
Properties: White crystals from isopropanol, mp 192-193°. LD50 in mice (mg/kg): 80 ±4.6 i.v. (Lafon).
Melting point: mp 192-193°
Toxicity data: LD50 in mice (mg/kg): 80 ±4.6 i.v. (Lafon)
Therap-Cat: Vasodilator (peripheral).
Keywords: Vasodilator (Peripheral). |