Title: Cafaminol
CAS Registry Number: 30924-31-3
CAS Name: 3,7-Dihydro-8-[(2-hydroxyethyl)methylamino]-1,3,7-trimethyl-1H-purine-2,6-dione
Additional Names: 8-[(2-hydroxyethyl)methylamino]caffeine; 8-(b-oxyethyl)methylaminocaffeine; methylcoffanolamine
Trademarks: Rhinoptil (Promonta)
Molecular Formula: C11H17N5O3
Molecular Weight: 267.28
Percent Composition: C 49.43%, H 6.41%, N 26.20%, O 17.96%
Literature References: Alkanolamine deriv of caffeine, q.v. Prepn: J. Klosa, DE 1085530; eidem, US 3094531 (1958, 1963 both to Delmar Chemicals Ltd.). Efficacy studies: E. Szirmai, Praxis 13, 412 (1969); R. Leypoldt, Therapiewoche 26, 3381 (1976). Bioavailability and absorption kinetics in humans: H. Walther, K. Kochler, Pharmazie 34, 375 (1979).
Properties: Colorless crystals from ethanol, mp 162-164°. Soly in water is about 6%; pH of aq solns is 6.9. LD50 s.c. in male mice: 700 mg/kg (Klosa).
Melting point: mp 162-164°
Toxicity data: LD50 s.c. in male mice: 700 mg/kg (Klosa)
Therap-Cat: Decongestant (nasal).
Keywords: Decongestant. |