Title: Camazepam
CAS Registry Number: 36104-80-0
CAS Name: Dimethylcarbamic acid 7-chloro-2,3-dihydro-1-methyl-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl ester
Additional Names: 7-chloro-1,3-dihydro-3-hydroxy-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one dimethylcarbamate (ester); 7-chloro-1,3-dihydro-3-(N,N-dimethylcarbamoyl)-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one
Manufacturers' Codes: SB-5833
Trademarks: Albego (Boehringer, Ing.)
Molecular Formula: C19H18ClN3O3
Molecular Weight: 371.82
Percent Composition: C 61.37%, H 4.88%, Cl 9.53%, N 11.30%, O 12.91%
Literature References: Prepn: G. Ferrari, C. Casagrande, DE 2142181; eidem, US 3799920 (1972, 1974 both to Siphar). Metabolism: F. Marcucci et al., J. Pharm. Sci. 67, 1470 (1978). Pharmacology: L. Merlo et al., Arzneim.-Forsch. 24, 1759 (1974); R. Ferrini et al., ibid. 2029. Clinical studies: A. Tammaro et al., ibid. 27, 2177 (1978); S. Carrara et al., Eur. J. Clin. Pharmacol. 13, 335 (1978).
Properties: White crystalline powder from ethyl acetate, mp 173-174°. Sol in alcohol, moderately sol in water. LD50 in mice, rats (mg/kg): 970, >4000 orally (Ferrini).
Melting point: mp 173-174°
Toxicity data: LD50 in mice, rats (mg/kg): 970, >4000 orally (Ferrini)
NOTE: This is a controlled substance (depressant): 21 CFR, 1308.14.
Therap-Cat: Anxiolytic.
Keywords: Anxiolytic; Benzodiazepine Derivatives. |