Title: Canfosfamide
CAS Registry Number: 158382-37-7
CAS Name: (2R)-L-g-Glutamyl-3-[[2-[[bis[bis(2-chloroethyl)amino]phosphinyl]oxy]ethyl]sulfonyl]-L-alanyl-2-phenylglycine
Additional Names: g-glutamyl-a-amino-b-((2-ethyl-N,N,N¢,N¢-tetrakis(2-chloro)ethylphosphoramidate)sulfonyl)propionyl-(R)-(-)phenylglycine
Manufacturers' Codes: TER-286
Molecular Formula: C26H40Cl4N5O10PS
Molecular Weight: 787.47
Percent Composition: C 39.66%, H 5.12%, Cl 18.01%, N 8.89%, O 20.32%, P 3.93%, S 4.07%
Literature References: Nitrogen mustard prodrug preferentially activated by glutathione S-transferase P1-1. Prepn: M. H. Lyttle et al., J. Med. Chem. 37, 1501 (1994); L. M. Kauvar et al., WO 9509866; eidem, US 5556942 (1995, 1996 both to Terrapin). Mechanism of activation: A. Satyam et al., J. Med. Chem. 39, 1736 (1996). In vitro and in vivo antitumor and myelosuppressive effects: A. S. Morgan et al., Cancer Res. 58, 2568 (1998). Clinical pharmacokinetics and toxicology in advanced solid malignancies: L. S. Rosen et al., Clin. Cancer Res. 9, 1628 (2003); idem et al., ibid. 10, 3689 (2004).
Properties: White solid, mp 82-90°.
Melting point: mp 82-90°
Derivative Type: Hydrochloride
CAS Registry Number: 439943-59-6
Manufacturers' Codes: TLK-286
Trademarks: Telcyta (Telik)
Molecular Formula: C26H40Cl4N5O10PS.HCl
Molecular Weight: 823.94
Percent Composition: C 37.90%, H 5.02%, Cl 21.51%, N 8.50%, O 19.42%, P 3.76%, S 3.89%
Therap-Cat: Antineoplastic.
Keywords: Antineoplastic; Alkylating Agents; Nitrogen Mustards. |