Title: Cholestyramine Resin
CAS Registry Number: 11041-12-6
Additional Names: Colestyramin
Manufacturers' Codes: Dowex 1-X2-Cl; MK-135
Trademarks: Cholybar (Warner-Lambert); Cuemid (Merck & Co.); Quantalan (BMS); Questran (BMS)
Literature References: A synthetic, strongly basic anion exchange resin contg quaternary ammonium functional groups which are attached to a styrene-divinylbenzene copolymer. Main constituent: Polystyrene trimethylbenzylammonium as Cl- anion, also contains divinylbenzene. Av polymeric mol wt >106; Cl- content 14-17%. Effect of particle size on bile salt binding capacity: L. M. Hagerman et al., Proc. Soc. Exp. Biol. Med. 139, 248 (1972). Review of pharmacology: H. R. Casdorph in Lipid Pharmacology Vol. 2(2), R. Paoletti, C. J. Glueck, Eds. (Academic Press, New York, 1976) pp 222-256. Clinical evaluation in chlordecone detoxification: W. J. Cohn et al., N. Engl. J. Med. 298, 243 (1978). Review of pharmacology and therapeutic efficacy: M. Ast, W. H. Frishman, J. Clin. Pharmacol. 30, 99-106 (1990).
Properties: White to buff-colored, hygroscopic, fine powder. Odorless or has not more than a slight amine-like odor. Insol in water, alcohol, benzene, chloroform, ether.
Therap-Cat: Antilipemic; ion-exchange resin (bile salts).
Keywords: Antilipemic; Bile Acid Sequesterants; Ion-exchange Resin. |