Title: Cloperastine
CAS Registry Number: 3703-76-2
CAS Name: 1-[2-[(4-Chlorophenyl)phenylmethoxy]ethyl]piperidine
Additional Names: 1-[2-[(p-chloro-a-phenylbenzyl)oxy]ethyl]piperidine; p-chlorobenzhydryl 2-(1-piperidyl)ethyl ether
Molecular Formula: C20H24ClNO
Molecular Weight: 329.86
Percent Composition: C 72.82%, H 7.33%, Cl 10.75%, N 4.25%, O 4.85%
Literature References: Prepn: GB 670622 (1952 to Parke, Davis); Fujie, Yakugaku Zasshi 81, 693 (1961), C.A. 55, 25848f (1961). Prepn of salts: GB 1179945 (1970 to Yoshitomi Pharm.), C.A. 72, 132549g (1970). Pharmacology: Takagi et al., Yakugaku Zasshi 85, 550 (1965); 87, 907 (1967), C.A. 63, 8932f (1965); 67, 107101u (1967). Metabolism: Kato, Furuta, Oyo Yakuri 5, 735 (1972).
Properties: bp0.06 172-174°, bp0.15 178-180°.
Boiling point: bp0.06 172-174°; bp0.15 178-180°
Derivative Type: Hydrochloride
CAS Registry Number: 14984-68-0
Trademarks: Hustazol (Yoshitomi); Nitossil (Zyma); Novotusil (Inpharzam); Seki (Simes)
Molecular Formula: C20H24ClNO.HCl
Molecular Weight: 366.32
Percent Composition: C 65.57%, H 6.88%, Cl 19.36%, N 3.82%, O 4.37%
Properties: Crystals, mp 147.9°.
Melting point: mp 147.9°
Derivative Type: Methiodide
Molecular Formula: C20H24ClNO.CH3I
Molecular Weight: 471.80
Percent Composition: C 53.46%, H 5.77%, Cl 7.51%, N 2.97%, O 3.39%, I 26.90%
Properties: Crystals, mp 140°.
Melting point: mp 140°
Therap-Cat: Antitussive.
Keywords: Antitussive. |