Title: Detaxtran
CAS Registry Number: 9015-73-0
CAS Name: Dextran 2-(diethylamino)ethyl ether
Additional Names: diethylaminoethyldextran; DEAE-dextran; basic dextran
Literature References: Cationic derivative of dextran, q.v., with antilipemic activity. Prepn: W. McKernan, C. R. Ricketts, Chem. Ind. (London) 1959, 1490; E. Antonini et al., G. Biochem. 14, 88 (1965); C.A. 63, 4375h (1965). Effect on platelet aggregation: R. Brossmer, Th. Pfleiderer, Naturwissenschaften 53, 464 (1966); A. Larcon et al., Experientia 28, 1096 (1972). Use to lower hypercholesterolemia: T. M. Parkinson, US 3627872 (1971 to Upjohn); to reduce blood lipid levels: F. Kuzuya et al., US 3851057 (1974 to Meito Sangyo). Clinical trial in hyperlipoproteinemia: F. Pupita, A. Barone, Int. J. Clin. Pharmacol. Res. 3, 287 (1983).
Properties: Powder, soluble in water, saline.
Derivative Type: Hydrochloride
CAS Registry Number: 9064-91-9
Trademarks: Dexide (Sanofi-Synthelabo); Pulsar (Medosan)
Therap-Cat: Antilipemic.
Keywords: Antilipemic. |