Title: Dorzolamide
CAS Registry Number: 120279-96-1
CAS Name: (4S,6S)-4-(Ethylamino)-5,6-dihydro-6-methyl-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide
Molecular Formula: C10H16N2O4S3
Molecular Weight: 324.44
Percent Composition: C 37.02%, H 4.97%, N 8.63%, O 19.73%, S 29.65%
Literature References: Carbonic anhydrase inhibitor. Prepn: J. J. Baldwin et al., EP 296879; eidem, US 4797413 (1988, 1989 both to Merck & Co.). Mechanism of action study: R.-F. Wang et al., Arch. Ophthalmol. 109, 1297 (1991). HPLC determn in plasma and urine: B. K. Matuszewski, M. L. Constanzer, Chirality 4, 515 (1992). Clinical evaluations in glaucoma and ocular hypertension: E. A. Lippa et al., Ophthalmology 98, 308 (1991); E. A. Lippa et al., Arch. Ophthalmol. 110, 495 (1992).
Derivative Type: Hydrochloride
CAS Registry Number: 130693-82-2
Manufacturers' Codes: MK-507
Trademarks: Trusopt (Merck & Co.)
Molecular Formula: C10H16N2O4S3.HCl
Molecular Weight: 360.90
Percent Composition: C 33.28%, H 4.75%, N 7.76%, O 17.73%, S 26.65%, Cl 9.82%
Properties: mp 283-285°. [a]D24 -8.34° (c = 1 in methanol). Sol in water.
Melting point: mp 283-285°
Optical Rotation: [a]D24 -8.34° (c = 1 in methanol)
Therap-Cat: Antiglaucoma agent.
Keywords: Antiglaucoma; Carbonic Anhydrase Inhibitor. |