Title: Dyphylline
CAS Registry Number: 479-18-5
CAS Name: 7-(2,3-Dihydroxypropyl)-3,7-dihydro-1,3-dimethyl-1H-purine-2,6-dione
Additional Names: 7-(2,3-dihydroxypropyl)theophylline; (1,2-dihydroxy-3-propyl)theophylline; glyphylline; glyfyllin; diprophylline; AFI-phyllin
Trademarks: Astmamasit (Showa Yakuhin); Asthmolysin (Kade); Astrophyllin; Circair (Circle); Coronarin; Cor-Theophyllin (Paramedical); Dilor (Savage); Hiphyllin; Hyphylline; Lufyllin (Mallinckrodt); Neostenovasan; Neothylline (Lemmon); Neotilina; Neo-Vasophylline; Neutrafil; Neutraphylline (Dorsey); Prophyllen (Streuli); Silbephylline (Berk); Solufilin; Solufyllin; Theal ampules (Boehringer, Mann.); Thefylan
Molecular Formula: C10H14N4O4
Molecular Weight: 254.24
Percent Composition: C 47.24%, H 5.55%, N 22.04%, O 25.17%
Literature References: Prepn: Jones, Maney, US 2575344 (1951 to State Univ. of Iowa); Roth, Arch. Pharm. 292, 234 (1959). Toxicity data: R. A. Al'tshuler, Med. Prom. SSSR 16, 57 (1962), C.A. 61, 6230g (1964).
Properties: Extremely bitter crystals from alcohol, mp 158°. uv max (0.001% in H2O): 273 nm (A1%1cm 361). Freely sol in water; one gram dissolves in 3 ml H2O at 25°. Soly (g/100 ml): alc 2; chloroform 1. pH (1% aq soln) 6.6 to 7.3. LD50 in mice (mg/kg): 3400 orally; 1430 s.c. (Al'tshuler).
Melting point: mp 158°
Absorption maximum: uv max (0.001% in H2O): 273 nm (A1%1cm 361)
Toxicity data: LD50 in mice (mg/kg): 3400 orally; 1430 s.c. (Al'tshuler)
Therap-Cat: Bronchodilator.
Keywords: Bronchodilator; Xanthine Derivatives. |